ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
Abstract
The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.................
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Canadian PM Trudeau, caught between his enthusiasms for trans and Muslims, steps in a giant cowpie
The needle on my schadenfreude meter jumped so hard to the right that it’s stuck there in red zone, where my soul is endangered by excessive pleasure in the suffering of another. It must be because I find Canada’s Prime Minister Justin Trudeau such a phony doofus, pretending to be a model of unpretentious tolerance while destroying the civil liberties of his opponents (as in the brutal repression of the Ottawa Freedom Convoy demonstrations against his extreme Covid lockdown).
The former high school drama teacher certainly loves role playing, including costumes, as in his notorious familial cosplay during a trip to India 5 years ago that was so over the top that many locals felt uncomfortable:.......
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The desire for technocracy Рor techn̩cracy?
Mattias Desmet
An online survey requested by VRT (the national broadcaster here in Belgium) and the newspaper De Standaard shows that 60% of Flemish people are in favor of replacing democracy with a technocracy – a form of government in which experts make decisions instead of democratically elected politicians. In fact, 35% also want a strong leader "who doesn't have to worry about parliament and elections".
A survey is just a survey, of course. In the same study, 81% of respondents also say they swear by a democratic system. These conflicting results could mean anything. That the survey should not be taken seriously. Or that man doesn’t always know what he desires.
In any case, I assume that VRT is not surprised by the population's inclination for technocracy. Have they not done exactly this in the last three years: created public broadcasting in which politicians were put behind society's school desks as children and the ‘experts’ as teachers at the front of the class? Let me add right away: I’m not surprised that the mainstream media has chosen this approach. And certainly not that part of the population goes along with it. Within the dominant view of man and the world, this choice is not only perfectly logical, it is an ethical duty................
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Journalists Attacking The Film ‘Sound Of Freedom’ Should Have Their Hard Drives Investigated
By Brandon Smith
I recently went to see the movie Sound Of Freedom with the expectation of a moderate level of political commentary or religious pontificating, given the rabid and widespread attacks on the film by the leftist media. All I knew going in was that the indie production was about child trafficking and that the mainstream media HATES IT. After the film was over, my first thought was that it was an excellent story about a very dark and difficult issue. My second thought was – “What the hell was all the fuss about? There’s not a single political moment in the entire movie!”
The media war on the low budget flick is so bizarre given this fact that I am immediately suspicious of their intentions. Not one political message, not one momentary critique of the political left, not one moment where MAGA or Trump or “Q-Anon” is mentioned, not one “conspiracy theory.” So why all the hate?
Before reading this review any further I highly recommend you check out some of the hatchet job articles published about Sound Of Freedom to get a sense of what I’m talking about – examples are here, here, here and here.
The first thing you’ll probably notice is that the majority of these vitriolic diatribes use the exact same talking points – They suggest that The Sound Of Freedom is based in conspiracy theory, far-right extremism and that it is funded by a subversive network of “Q-Anon adjacent” conservatives. Some journalists have even attacked the veracity of the film’s true story – the career of DHS agent Tim Ballard, who operated covertly to take down child sex traffickers in Central America...............
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Randy Hillier, former Member of Ontario Provincial Parliament, was one of the most powerful voices against government COVID mandates. He founded No More Lockdowns, an organization that provided lawn signs, and organized protests and gatherings for Ontarians who opposed restrictions and mandatory vaccination. When thousands of Freedom Convoy truck drivers and their supporters converged on Parliament Hill to protest border restrictions on the unvaccinated, Randy was there, lending his support.
A couple of weeks ago I noticed a Tweet by Randy saying that he had an impersonator on Twitter. I was shocked when I tried to report the imposter and, even though Randy and I follow each other, I was not able to find Randy’s real profile when I did a Twitter search for him.
Randy’s real Twitter profile was being hidden, and someone pretending to be him was showing up in the search instead. It was mind-boggling to think that a former Parliamentarian with nearly 75,000 followers would be completely suppressed in the search, so I decided to reach out to Randy and see what else has been going on in his life since the mandates were lifted...................
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The Pentagon planned to use its biolaboratories in Africa to test unregistered medicines on local populations for the sake of “big pharma,” Tass reported on 19 July, based on documents found in Ukraine.
According to the Chief of Russia’s Radiation, Chemical and Biological Protection Troops, Lieutenant General Igor Kirillov, documents found by the Russian military at a US biolaboratory in Ukraine indicate that the Pentagon planned to use the US army to test unregistered medical drugs on the local population in African countries. The testing would involve biolaboratories and facilitating agencies, such as Metabiota, which has links to Hunter Biden, son of US President Joe Biden. The results would then be provided to US regulatory agencies "in the interests of the so-called big pharma."
"We have repeatedly pointed to the company’s ties with the son of the US incumbent president, Hunter Biden, and government organizations. Notably, Metabiota’s representatives admit that, as a matter of fact, they are establishing ties to ensure the Pentagon and other American agencies’ work abroad," Kirillov added.
He also said that Ukraine’s Science and Technology Center and other Pentagon contractors were taking an active part in these activities.............
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https://thegrayzone.com/2023/07/20/resolutions-emergency-iraq-syria-libya-yemen/
DC Uniparty kills House resolutions to end US emergency powers in Iraq, Syria, Libya and Yemen
By:
In a massive show of support for limitless executive power, Congress rejected legislation that would have terminated national emergency powers allowing Washington to wage war across the Middle East – and to test biological weapons on US citizens.
Led by Representative Paul Gosar, a handful of Republican members of Congress launched a protest against 41 nominal “national emergency” declarations, many of which are decades old.
Rep. Gosar has argued the National Emergencies Act is “tyrannical,” granting 148 separate powers to the executive branch.
This July 18, the House voted down five resolutions to terminate national emergency powers which date back as far as 2003. The countries affected by the five resolutions include Congo, Yemen, Libya, Syria and Iraq.
Each vote saw a coalition of pro-war Democrats and Republicans join together in overwhelming numbers to protect the executive branch’s emergency authorities.
Among the emergency declarations still in effect is one authorizing war on Libya on the basis that Muammar Ghadhafi posed an urgent threat to the US; one enabling economic warfare on Syria on the specious grounds that Damascus sponsors international terrorism; and another allowing the president to support Saudi Arabia’s military assault on Yemen, which resulted in the world’s worst humanitarian catastrophe.
Yet another emergency declaration provides the authority for the US government to test biological weapons on American citizens..................
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